CLDF Title
Home | Contact Us | Bookmark
About CLDF Centers of Educational Expertise  
Live CME Meetings Webcasts Slide Library Abstract Library Conference Highlights
Reuters Health Information (2003-10-02): Lower neuroblastoma rates linked to folate fortification


Lower neuroblastoma rates linked to folate fortification

Last Updated: 2003-10-02 9:45:26 -0400 (Reuters Health)

NEW YORK (Reuters Health) - Since Canada began fortifying its flour with folate in 1997, neuroblastoma rates have dropped considerably, new research suggests.

Maternal folic acid intake has been tied to a decreased risk of several childhood cancers, but its relationship to the risk of neuroblastoma was not known.

Dr. Gideon Koren, from The Hospital for Sick Children in Toronto, and colleagues used data from an Ontario cancer registry to determine the rates of neuroblastoma, acute lymphoblastic leukemia (ALL), and hepatoblastoma before and after folate food fortification occurred.

The researchers' findings are reported in Clinical Pharmacology and Therapeutics for September.

Prior to fortification, 1.57 cases of neuroblastoma were seen for every 10,000 births, the authors note. After fortification, the incidence fell significantly to 0.62 cases per 10,000 births (p < 0.0001). Moreover, a significant difference remained even after accounting for age and disease stage at diagnosis.

In contrast, ALL and hepatoblastoma rates did not change after folate fortification, the researchers point out.

"Although the incidence of neuroblastoma may have declined in association with folic acid fortification, longer follow-up data would better confirm these findings," the authors state.

"It also remains to be determined whether folic acid is efficacious as an additional agent in the management of existing neuroblastoma or for prevention of disease relapse in successfully treated patients," they conclude.

Clin Pharmacol Ther 2003;74:288-294.

Slide Library
Abstract Library
Slide Library
Abstract Library
Slide Library
Abstract Library
Live CME Meetings
Slide Library
Abstract Library
Slide Library
Abstract Library
CLDF Follow Us
About CLDF
Mission Statement
Board of Trustees
Board of Advisors
CLDF Supporters
Other Resources
Liver News Library
Journal Abstracts
Hep C Link to Care
Centers of
Educational Expertise
Substance Use Disorder
  The Chronic Liver Disease Foundation is a non-profit organization with content developed specifically for healthcare professionals.
© Copyright 2012-2016 Chronic Liver Disease Foundation. All rights reserved. This site is maintained as an educational resource for US healthcare providers only.
Use of this Web site is governed by the Chronic Liver Disease Foundation terms of use and privacy statement.