Division of Gastroenterology, Department of Medicine, University of Washington School of Medicine, 1959 Northeast Pacific Street, Box 356175, Seattle, WA 98195-6175, USA. Electronic address: firstname.lastname@example.org.
Major complications of cirrhosis include the development of ascites, spontaneous bacterial peritonitis, hepatorenal syndrome, variceal hemorrhage, hepatic encephalopathy, and hepatocellular carcinoma. Careful evaluation and management of ascites and varices with judicious use of prophylactic therapy can improve survival. Diagnosis of hepatic encephalopathy can lead to appropriate intervention without protein restriction. Patients should undergo hepatocellular carcinoma surveillance routinely every 6 months. The development of any decompensating event should prompt referral to a liver transplant center.