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Characteristics of patients with nonalcoholic steatohepatitis who develop hepatocellular carcinoma |
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Yasui K, Hashimoto E, Komorizono Y, Koike K, Arii S, Imai Y, Shima T, Kanbara Y, Saibara T, Mori T, Kawata S, Uto H, Takami S, Sumida Y, Takamura T, Kawanaka M, Okanoue T; The Japan NASH Study Group, The Ministry of Health, Labour and Welfare of Japan. Clin Gastroenterol Hepatol. 2011 Feb 11. [Epub ahead of print] |
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Abstract
BACKGROUND & AIMS: Nonalcoholic steatohepatitis (NASH) can progress to hepatocellular carcinoma (HCC). We aimed to characterize the clinical features of NASH patients with HCC.
METHODS: In a cross-sectional multicenter study in Japan, we examined 87 patients (median age 72 years, 62% male) with histologically proven NASH who developed HCC. The clinical data were collected at the time HCC was diagnosed.
RESULTS: Obesity (body mass index ≥25 kg/m2), diabetes, dyslipidemia, and hypertension were present in 54 (62%), 51 (59%), 24 (28%), and 47 (55%) patients, respectively. In non-tumor liver tissues, the degree of fibrosis was stage 1 in 10 patients (11%), stage 2 in 15 (17%), stage 3 in 18 (21%), and stage 4 (i.e., liver cirrhosis) in 44 (51%). The prevalence of cirrhosis was significantly lower among male patients (21 of 54; 39%), compared with female patients (23 of 33; 70%) (P = 0.008).
CONCLUSIONS: Most patients with NASH who develop HCC are men; the patients have a high rates of obesity, diabetes, and hypertension. Male patients appear to develop HCC at a less advanced stage of liver fibrosis than female patients.
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