Deparment of Surgical Oncology, Hepatobiliary Surgery Unit, Istituto Nazionale per lo Studio e la Cura dei Tumori di Napoli, “Fondazione G Pascale”, Naples, Italy.
AIMS AND BACKGROUND:
Extrahepatic spread of hepatocellular carcinoma (HCC) diagnosed during the clinical course of the disease is not frequent; however, with the prolonged survival of HCC patients, the incidence of extrahepatic metastases seems to be increasing.
METHODS AND STUDY DESIGN:
We present four unusual cases of extrahepatic metastasis from HCC: the first concerns a patient who underwent a liver transplantation for HCC with cirrhosis and three years later developed metastases in the lung and the left orbit; the second is that of a patient who developed an extraperitoneal pararectal metastasis; in the third case a large osteolytic lesion developed on the left iliac bone, and in the fourth case we found an isolated metastasis in the left mandible.
RESULTS AND CONCLUSIONS:
These cases offer important information related to the unusual biology of isolated metastases from HCC after successful treatment of the primary cancer.